Cast of Best Medicine: Meet Every Actor and Character in 2026

The cast of Best Medicine has become one of the biggest reasons viewers are enjoying FOX’s new medical comedy-drama. With funny characters, emotional moments, small-town friendships, and an unusual doctor at the center of everything, the show offers something different from traditional hospital dramas. But who are the actors behind the people of Port Wenn?

The series stars Josh Charles as Dr. Martin Best, a brilliant but socially awkward surgeon who leaves Boston for a quieter life in a small fishing village. He soon discovers that treating patients is much easier than getting along with the people around him. Abigail Spencer, Annie Potts, Josh Segarra, and Cree bring humor and heart to the story.

Since premiering in January 2026, Best Medicine has attracted a growing audience. Its second season began in September 2026, introducing additional characters and new problems for Martin. This guide explores the main cast, supporting actors, their characters, previous roles, and the latest Season 2 updates.

Best Medicine Cast and Characters Overview

Here is a quick look at the main and supporting actors appearing in the series.

According to the official FOX Best Medicine cast information, the series features Josh Charles, Abigail Spencer, Annie Potts, Josh Segarra, and Cree as its leading stars.

Josh Charles as Dr. Martin Best

Josh Charles plays Dr. Martin Best, the central character of the series.

Martin is an extremely talented surgeon who once worked in Boston. He has excellent medical knowledge and can identify illnesses that other doctors might miss.

However, he has one major problem.

He is not particularly good at dealing with people.

Martin often speaks without considering how his words might make someone feel. His patients expect kindness and understanding, but he usually gives them blunt medical advice instead.

This creates many funny situations.

Why Martin Leaves Boston

Martin suddenly leaves his successful surgical career and moves to Port Wenn, a fictional fishing village in Maine.

He remembers spending summers there during childhood.

At first, moving to a quiet town might seem like a good decision.

However, Martin soon realizes that the residents are very interested in one another’s lives.

People gossip, ask personal questions, and expect their doctor to be friendly.

Martin prefers silence and privacy.

This difference creates much of the show’s comedy.

Behind his difficult personality, Martin also struggles with a serious phobia of blood.

His condition affects his medical career and adds emotional depth to the story.

Where Have You Seen Josh Charles Before?

Josh Charles was born on September 15, 1971, in Baltimore, Maryland.

He became widely recognized through the movie Dead Poets Society in 1989.

He later starred in the popular television series Sports Night.

However, many viewers know him best as Will Gardner in The Good Wife.

His performance earned major award nominations and helped establish him as a respected television actor.

He has also appeared in The Veil, We Own This City, and The Power.

In Best Medicine, Charles uses his dramatic experience alongside comedy.

His performance makes Martin frustrating, funny, and surprisingly emotional.

Abigail Spencer as Louisa Gavin

Abigail Spencer plays Louisa Gavin, one of Port Wenn’s most important residents.

Louisa works in education and later becomes the principal of the local school.

She is friendly, intelligent, and deeply connected to the community.

Unlike Martin, she understands the importance of personal relationships.

She enjoys talking to people and helping them through problems.

When Martin arrives, their personalities immediately clash.

Louisa and Martin’s Complicated Relationship

Louisa finds Martin interesting, even though his behavior often annoys her.

Martin also develops feelings for Louisa.

However, expressing those emotions is difficult for him.

He can explain complicated medical conditions without hesitation, but a simple romantic conversation can become a disaster.

Their relationship develops through misunderstandings, arguments, and moments of unexpected kindness.

This romantic storyline becomes one of the central parts of Best Medicine.

Season 2 introduces additional complications when another man begins showing interest in Louisa.

Abigail Spencer’s Acting Career

Abigail Spencer was born on August 4, 1981, in Gulf Breeze, Florida.

She began gaining attention through television roles.

Her early career included an appearance in the soap opera All My Children.

She later appeared in Mad Men, Suits, and Rectify.

One of her most recognizable performances came in Timeless, where she played Lucy Preston.

She has also appeared in Grey’s Anatomy and 9-1-1.

Her experience with emotional and romantic television stories makes her a natural fit for Louisa.

Annie Potts as Aunt Sarah

Annie Potts plays Sarah Best, Martin’s aunt.

Sarah is one of the most important people in Martin’s personal life.

She lives in Port Wenn and works as a lobster fisher.

Unlike her nephew, Sarah understands the town’s unusual personalities.

She knows how the local community works and often tries to help Martin adjust.

However, she does not always agree with his behavior.

Sarah Understands Martin Better Than Most People

Sarah has known Martin since he was young.

She understands that his difficult personality does not mean he is incapable of caring about others.

She sometimes challenges him when he becomes too harsh.

Other times, she offers support when he struggles with problems he does not want to discuss.

Their relationship gives the series an emotional family connection.

Sarah also has an independent personality.

She is strong, practical, and comfortable speaking her mind.

Her scenes often bring warmth and humor to the show.

Annie Potts Is a Familiar Hollywood Star

Annie Potts was born on October 28, 1952, in Nashville, Tennessee.

She has enjoyed a long career in movies and television.

Many viewers recognize her as Janine Melnitz from Ghostbusters.

She also played Mary Jo Shively in Designing Women.

Younger audiences may know her as Meemaw in Young Sheldon.

Her voice work includes Bo Peep in the Toy Story movies.

In Best Medicine, Potts brings her comedy experience to a character who can be loving, sarcastic, and entertaining.

Josh Segarra as Sheriff Mark Mylow

Josh Segarra plays Sheriff Mark Mylow, the local law enforcement officer in Port Wenn.

Mark is friendly, outgoing, and comfortable talking to almost everyone.

He has a very different personality from Dr. Martin Best.

While Martin often creates awkward situations, Mark usually tries to make people feel welcome.

However, their relationship becomes complicated because of Louisa.

Mark’s History With Louisa

Mark and Louisa were previously engaged.

Although their relationship ended, they remain connected through their lives in the same town.

Mark still cares about Louisa.

This creates tension when Martin begins developing romantic feelings for her.

Mark’s friendly personality makes him an interesting contrast to the doctor.

He is not simply an obstacle in the romance.

He also has his own emotions, responsibilities, and connection to the community.

Josh Segarra’s Previous Roles

Josh Segarra was born on June 3, 1986, in Longwood, Florida.

He has appeared in television dramas, comedies, and stage productions.

Many viewers remember him as Adrian Chase in Arrow.

He also appeared in Chicago P.D., The Other Two, and Scream VI.

More recently, he became known for his performance in Sirens.

His energetic acting style works well with Mark’s cheerful and sometimes awkward personality.

Cree as Elaine Denton

Cree plays Elaine Denton, Martin’s assistant at the local medical practice.

Elaine is young, confident, and familiar with the town’s residents.

She helps manage the daily activities of the medical office.

However, working for Martin is not always easy.

His strict personality and unusual expectations create problems.

Elaine often responds with humor or frustration.

Elaine Has an Important Medical Responsibility

Elaine is more than a receptionist.

She is also trained as a phlebotomist, meaning she can collect blood samples.

This becomes especially important because Martin struggles with blood-related medical procedures.

Her ability to perform blood draws helps him continue working.

However, the arrangement eventually creates professional difficulties.

The medical board becomes concerned about how Martin is handling certain responsibilities.

This issue becomes part of the second season’s storyline.

Who Is Cree?

Cree, previously credited as Cree Cicchino, was born on May 9, 2002, in Queens, New York.

She became famous as Babe Carano in Nickelodeon’s Game Shakers.

She later appeared in Mr. Iglesias and The Sleepover.

Her work in Best Medicine gives her an opportunity to perform alongside experienced television actors.

Elaine brings younger energy to the cast and helps create some of the show’s funniest workplace moments.

Stephen Spinella as Greg Garrison

Stephen Spinella plays Greg Garrison, one of the owners of The Salty Breeze.

The restaurant is an important gathering place for Port Wenn residents.

Greg runs the business with his husband, George Brady.

Their restaurant becomes a place where townspeople meet, talk, and discuss local events.

A Bigger Role in Season 2

Greg first appeared as a recurring character in Season 1.

However, his importance increased as the series continued.

In 2026, Stephen Spinella was promoted to a series regular for the second season.

This gave the writers more opportunities to explore Greg’s personality and relationship with George.

Stephen Spinella is also a respected theater actor.

He received Tony Awards for his performances in Angels in America.

His long experience in dramatic and comedic storytelling adds depth to his character.

Jason Veasey as George Brady

Jason Veasey plays George Brady, Greg’s husband.

George works as the executive chef at The Salty Breeze.

Together, George and Greg run one of the town’s most recognizable businesses.

Their relationship brings warmth and humor to the series.

While Martin frequently struggles with ordinary social situations, the couple generally understands how to connect with the community.

George Becomes a Main Character

Like Stephen Spinella, Jason Veasey was promoted to a series regular for Season 2.

This change shows how important Greg and George have become to the show’s world.

Their scenes help expand the story beyond Martin’s medical office.

Viewers learn more about the town through the people who live and work there.

Veasey has previous experience in television and theater, including appearances in Only Murders in the Building.

His performance helps make George an engaging part of the ensemble.

Didi Conn as Geneva Potter

Didi Conn portrays Geneva Potter, a local councilwoman.

Geneva is involved in the community’s affairs.

She often has strong opinions about what should happen in Port Wenn.

Her personality can create problems for Martin, who does not enjoy dealing with local politics or community disagreements.

Geneva adds another entertaining voice to the town.

Didi Conn’s Famous Roles

Didi Conn was born on July 13, 1951, in Brooklyn, New York.

She is best known for playing Frenchy in the musical film Grease.

She returned to the character in Grease 2.

Conn has also appeared in several television productions.

Her recognizable voice and cheerful screen presence help make Geneva memorable.

Clea Lewis as Sally Mylow

Clea Lewis plays Sally Mylow, the town’s pharmacist.

Sally is also Sheriff Mark Mylow’s mother.

Her position gives her an important connection to both the healthcare system and local family relationships.

As a pharmacist, she frequently deals with medical matters.

This creates opportunities for interactions with Martin.

Her connection to Mark also gives her a personal interest in events involving Louisa.

Clea Lewis previously appeared in Ellen and The Perfect Man.

She brings experience in comedy to the supporting cast.

John DiMaggio and Carter Shimp as Bert and Al Large

John DiMaggio plays Bert Large, a local handyman.

Bert is one of Port Wenn’s familiar faces.

He works with his son, Al Large, played by Carter Shimp.

Their relationship adds another family dynamic to the series.

The two become involved in different activities around town.

John DiMaggio’s Famous Voice Acting Career

John DiMaggio is especially well known for voice acting.

He voices Bender in Futurama and Jake the Dog in Adventure Time.

He has also worked on many animated television programs and video games.

His appearance in Best Medicine allows audiences to see him in a live-action role.

Carter Shimp, meanwhile, plays Al, whose growing connection with Elaine creates additional interest.

The characters bring humor to everyday situations around Port Wenn.

Martin Clunes as Dr. Robert Best

One of the most exciting guest appearances comes from Martin Clunes.

He plays Dr. Robert Best, Martin’s father.

However, his involvement is special for another reason.

Clunes originally played the title character in the British series Doc Martin.

That show inspired the American adaptation.

The Connection Between Doc Martin and Best Medicine

The original British series followed Dr. Martin Ellingham, a successful surgeon who moved to a small Cornish village.

Like Martin Best, he was brilliant at medicine but struggled with social relationships.

The show became popular for its unusual characters and coastal setting.

Martin Clunes played the lead role throughout the original series.

His appearance in Best Medicine connects the new American version to its British inspiration.

Rather than simply repeating his old character, he plays the American doctor’s father.

This casting choice became a special treat for viewers familiar with both shows.

New Cast Members in Best Medicine Season 2

The second season introduced new characters who brought additional problems into Martin’s life.

Some characters affect his professional responsibilities.

Others create complications in his personal relationships.

These additions help the story move beyond the conflicts established during the first season.

Jack Cutmore-Scott as Parker

Jack Cutmore-Scott joined Season 2 as Parker.

Parker arrives in Port Wenn to monitor Martin’s medical practice.

His assignment follows concerns about Martin’s professional conduct and reliance on Elaine for blood draws.

Parker is friendly, charming, and comfortable around people.

Naturally, Martin finds him irritating.

The situation becomes even more complicated when Parker develops romantic chemistry with Louisa.

This creates another obstacle for Martin.

Jack Cutmore-Scott previously appeared in Frasier, Deception, Oppenheimer, and Tenet.

His character adds both professional and romantic tension to the second season.

Eliza Coupe as Dr. Eden Montgomery

Eliza Coupe plays Dr. Eden Montgomery.

Eden is connected to Martin’s previous life and returns during the second season.

Her appearance introduces another professional medical character into the story.

She also has connections with Sarah and Martin that give their scenes additional meaning.

Eliza Coupe is known for her roles in Scrubs, Happy Endings, and Future Man.

Her comedy background makes her a suitable addition to the cast.

Andrea Martin as Judith

Andrea Martin joined the second season as Judith, a friend of Aunt Sarah.

Judith is an unusual and outspoken woman.

Her habits create problems that require Martin and Sarah to become involved.

Andrea Martin is an award-winning actress with extensive television and theater experience.

She is known for SCTV, Great News, and numerous Broadway productions.

Her guest appearance brings another experienced comedy performer into the show.

What Is Best Medicine About?

At its heart, Best Medicine is a story about a talented doctor who does not understand the people around him.

Martin Best is excellent at diagnosing medical problems.

However, his personal relationships are far more difficult.

When he moves from Boston to Port Wenn, he expects a quieter life.

Instead, he discovers a town full of unusual personalities.

Residents regularly ask for his help.

Some want medical treatment.

Others want advice, attention, or simply someone to listen to their problems.

Martin is not naturally comfortable with any of this.

Yet the more time he spends in Port Wenn, the more he becomes involved in the community.

The series combines medical mysteries, romantic complications, and small-town humor.

It also explores loneliness, friendship, emotional difficulties, and the importance of human connection.

That mixture helps separate the show from traditional hospital dramas.

When Did Best Medicine Premiere?

Best Medicine premiered on FOX on January 4, 2026.

Its first season introduced viewers to Martin and the residents of Port Wenn.

The show quickly attracted attention because of its unusual combination of comedy and medical storytelling.

In March 2026, FOX announced that it had renewed the series for a second season.

Season 2 began with a special premiere on September 20, 2026, followed by its regular Tuesday schedule beginning September 22.

The second season expands the stories involving Martin, Louisa, Elaine, Sarah, and the other town residents.

As of November 1, 2026, Season 2 is still airing.

Where Is Best Medicine Filmed?

Although Best Medicine takes place in the fictional Maine fishing village of Port Wenn, production uses locations in New York State.

The Hudson Valley region provides much of the show’s scenery.

Locations associated with production include Cornwall and surrounding areas.

These places help create the appearance of a quiet New England community.

The coastal atmosphere is important to the series.

Small streets, local businesses, and community gathering places make Port Wenn feel like a town where everybody knows everybody.

This setting also creates a contrast with Martin’s previous life in Boston.

He moves from a busy professional environment into a place where personal relationships are difficult to avoid.

Why the Best Medicine Cast Works So Well

One of the main strengths of Best Medicine is the difference between its characters.

Martin is serious, blunt, and uncomfortable in social situations.

Louisa is warm and understanding.

Sarah is practical and outspoken.

Mark is cheerful and friendly.

Elaine is confident and independent.

Greg and George bring warmth through their restaurant and community relationships.

These personalities create natural opportunities for comedy.

The actors also have different professional backgrounds.

Some, like Annie Potts and Andrea Martin, have decades of comedy experience.

Others, such as Josh Charles and Abigail Spencer, are especially known for dramatic television performances.

This combination allows the show to move between funny situations and emotional moments.

The cast helps viewers understand that Port Wenn is more than a setting.

It is a community of people whose lives are closely connected.

Interesting Facts About the Cast of Best Medicine

• The series is based on the British comedy-drama Doc Martin.

• Josh Charles plays the American version of the show’s difficult medical lead.

• Martin Clunes, who starred in the original British series, appears as Martin Best’s father.

• Annie Potts previously played Meemaw in Young Sheldon.

• Cree first became famous through Nickelodeon’s Game Shakers.

• John DiMaggio is known for voicing Bender in Futurama.

• Stephen Spinella and Jason Veasey became series regulars in Season 2.

• Jack Cutmore-Scott joined the second season as Parker.

• The fictional town of Port Wenn is located in Maine, but filming takes place in New York.

• Season 2 began airing in September 2026.

Final Thoughts

The cast of Best Medicine has helped turn a simple story about a difficult doctor into an entertaining television series.

Josh Charles leads the show with a performance that combines humor, frustration, and emotional depth.

Abigail Spencer brings warmth through Louisa, while Annie Potts adds experience and personality as Aunt Sarah.

Josh Segarra and Cree create many of the show’s entertaining moments through their characters.

Supporting actors such as Stephen Spinella, Jason Veasey, Didi Conn, and John DiMaggio help make the small town feel alive.

The addition of Jack Cutmore-Scott, Eliza Coupe, and Andrea Martin in Season 2 introduces new relationships and challenges.

As the show continues through 2026, its greatest strength remains the people of Port Wenn and the way their lives change after Martin arrives.

Frequently Asked Questions About the Best Medicine Cast

1. Who plays the main doctor in Best Medicine?

Josh Charles plays Dr. Martin Best, a talented former Boston surgeon who moves to Port Wenn and becomes the town’s general practitioner.

2. Who plays Louisa in Best Medicine?

Abigail Spencer plays Louisa Gavin, a local educator who develops a complicated romantic relationship with Martin.

3. Who plays Aunt Sarah in Best Medicine?

Annie Potts plays Sarah Best, Martin’s aunt and an experienced lobster fisher who lives in Port Wenn.

4. Who plays the sheriff in Best Medicine?

Josh Segarra plays Sheriff Mark Mylow, a friendly local officer who has a romantic history with Louisa.

5. Is Martin Clunes in Best Medicine?

Yes. Martin Clunes, the original star of Doc Martin, appears as Dr. Robert Best, Martin’s father.

6. Who are the new actors in Best Medicine Season 2?

Notable Season 2 additions include Jack Cutmore-Scott as Parker and Andrea Martin as Judith. Eliza Coupe also appears as Dr. Eden Montgomery.

7. Is Best Medicine returning for Season 2 in 2026?

Yes. FOX renewed the series in March 2026. Season 2 premiered in September 2026 and continues airing during the fall television season.

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